Associations of prenatal substance exposures with behavioral, mental, cognitive, and neuroimaging outcomes. Left, a plot of the largest -log10 p-values of the health associations among four prenatal substance exposures and polysubstance use at the baseline. Right, significant health associations of each prenatal substance exposure after false discovery rate correction in preadolescents at the baseline. Squares represent the associations that remained significant after controlling for the context variables. Triangles represent the associations confounded by the context variables. Orange indicates positive associations and green indicates negative associations. Credit: Gu et al.
An observational study has found links between prenatal substance exposure and mental health in children aged 10–12 years, but also found that controlling for environment and genetics eliminated many associations. The paper is published in the journal PNAS Nexus.
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