Identified brain circuitry bridges neural and behavioral roles in PTSD

Medical Express June 21, 2017 Medical, Michigan, Reviews

PTSD
Regions of the brain associated with stress and posttraumatic stress disorder. Credit: National Institutes of Health

Specific cerebral circuitry bridges chemical changes deep in the brain and the more outward behavioral expressions associated with post-traumatic stress disorder (PTSD), which could lead to more objective biomarkers for the disorder, according to a comprehensive review of rapidly changing data published June 22 in the New England Journal of Medicine.

In this latest, comprehensive review, the authors—from the Steven and Alexandra Cohen Veterans Center (CVC) in the Department of Psychiatry at NYU Langone Medical Center and the University of Michigan/Veterans Affairs Ann Arbor Health Systems Mental Health Service – have identified four neural-behavioral models associated with PTSD. These models pinpoint specific circuits in the brain that “mediate” between chemical changes – which are being examined as possible PTSD biomarkers – and the expression of certain…

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