How your brain is wired to just say ‘yes’ to opioids

Overview of reward structures in the human brain. Credit: Oscar Arias-Carrión, Maria Stamelou, Eric Murillo-Rodríguez, Manuel Menéndez-González and Ernst Pöppel./Wikimedia.org, CC BY-SA

The mid-1980s was the era of cocaine and marijuana, when “Just Say No” was the centerpiece of the war on drugs and the government’s efforts to stem drug use and addiction. Since then, prescription opioids have become the nation’s drug scourge. The idea that mere willpower can fight this public health emergency is not only outdated, it’s scientifically misguided.

Medical history tells us that almost as long as there have been opioids – their use dates back to the third century – there have been opioid addicts.

Thirty years ago, I was a research scientist focused on addiction when I was asked to co-author a volume on prescription narcotics for the “Encyclopedia of Psychoactive Drugs.“…

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