Experimental designs of the induction (experiment 1) and expression (experiment 2) phase of cocaine-induced hyperlocomotion with a timeline. Groups were distributed according to the experiment. (*) Represents that the first and second injection during the sensitization period was administered concerning the group treatment. Both injections were applied on the same day. During the sensitization period, the injections were applied on the odd days (1, 3, 5, 7, 9, 11, 13, and 15). The first injection was applied in the open-field and two hours later in the animal´s home-cage. On the even days (2, 4, 6, 8, 10, 12, and 14), animals were not handled. Credit: Biomedicines (2023). DOI: 10.3390/biomedicines11020383
Scientists have identified the brain structures responsible for compulsive drug-seeking behaviors due to repeated use of cocaine. The findings, published in Biomedicines, identifies the structures involved and neural pathways activated with repeated exposure to the drug. Researchers hope the study could help inform…
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