Indopedia All Things Marijuana
CBD, the medically remarkable cannabinoid from marijuana works much better with other cannabinoids in ‘entourage.’ My last post covered some of the political wrangling, with some states passing CBD-only laws and thinking they are done with medical marijuana. This entourage effect proves them wrong, and show that whole plant extracts with multiple cannabinoids, especially THC, work far better than CBD-only medications.
A major problem with CBD-only medication is a bell-shaped dose-response. The authors of the new Israeli study point out that CBD, short for cannabidiol, provided powerful anti-inflammatory and pain relief when delivered orally or intraperitoneally, but the effect seemed highly dose-dependent. Too high or too low a dose of purified CBD provided less effect against inflammation and pain, making establishing dosing very difficult.
This problem was solved by using “plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD,” in other words, high CBD marijuana. The effects were spectacular:
In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally…
